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The biotransformation of xylazine, a widly used animal tranquilizer, was investigated in rats. After administration of xylazine, the existence of 2,6-dimethylphenylisothiocyanate, 2,6-dimenthyl-4-hydroxy-aniline and p-hydroxy-xylazine in urine was confirmed by the comparison with chemically prepared standards in GC/MS. The main metabolite, p-hydroxy xylazine was excreted as conjugated form.
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